USE OF MULLERIAN INHIBITING SUBSTANCE FOR TREATING TUMORS AND FOR MODULATING CLASS 1 MAJOR HISTOCOMPATIBILITY ANTIGEN EXPRESSION.

摘要

This application concerns the treatment of certain tumors using an effective amount of the glycoprotein Muellerian Inhibiting Substance (MIS). This application further concerns the treatment of certain tumors using an effective amount of the C-terminal fragment of MIS. Also, this application concerns DNA sequences encoding the C-terminal fragment of MIS, vectors containing the DNA sequence and transformed host cells capable of producing the C-terminal fragment. This application further concerns treating certain tumors by transfecting tumor cells with a gene coding for MIS or the C-terminal fragment of MIS. Gene therapy treatments for inhibiting growth of certain tumors are also provided. Further, this application concerns a method for modulating class I histocompatibility antigens with MIS and EGF.