| 发明名称 |
Immunosuppressive compounds |
| 摘要 |
This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit the prolyl peptidyl cis-trans isomerase (rotamase) activity of the FKBP and inhibit T cell activation. As such, the compounds of this invention can be used as immunosuppressive drugs to prevent or significantly reduce graft rejection in bone marrow and organ transplantations and for use in the treatment of a wide variety of autoimmune diseases in humans and other mammals.
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| 申请公布号 |
US5622970(A) |
申请公布日期 |
1997.04.22 |
| 申请号 |
US19950456572 |
申请日期 |
1995.06.01 |
| 申请人 |
VERTEX PHARMACEUTICALS, INCORPORATED |
发明人 |
ARMISTEAD, DAVID A.;BOGER, JOSHUA S.;MEYERS, HAROLD V.;SAUNDERS, JEFFREY O.;TUNG, ROGER D. |
| 分类号 |
A61K31/34;A61K31/16;A61K31/165;A61K31/341;A61K31/343;A61K31/357;A61K31/36;A61K31/38;A61K31/381;A61K31/395;A61K31/40;A61K31/401;A61K31/4025;A61K31/4427;A61K31/443;A61K31/4439;A61K31/445;A61K31/4525;A61K31/453;A61K31/454;A61K31/4545;A61P25/02;A61P37/06;C07C233/56;C07C235/12;C07C235/34;C07D207/08;C07D207/16;C07D211/60;C07D307/54;C07D317/60;C07D333/24;C07D401/06;C07D401/12;C07D403/06;C07D405/06;C07D409/06;(IPC1-7):A61K31/445 |
主分类号 |
A61K31/34 |
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