发明名称 |
Pneumococcal polysaccharide conjugate vaccine |
摘要 |
A novel conjugate vaccine comprising partially hydrolyzed, highly purified, capsular polysaccharide (Ps) from Streptococcus pneumoniae bacteria (pneumococci, Pn) linked to an immunogenic carrier protein, is produced by a new process. The conjugate is useful in the prevention of pneumococcal infections. Vaccines comprising a mixture of from one to ten different pneumococcal polysaccharide-immunogenic protein (Pn-Ps-PRO) conjugates induce broadly protective recipient immune responses against the cognate pathogens from which the polysaccharide components are derived. Young children and infants younger than 2 years old, normally unable to mount a protective immune response to the Pn-Ps alone, exhibit protective immune responses upon vaccination with these Pn-Ps-PRO conjugates.
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申请公布号 |
US5623057(A) |
申请公布日期 |
1997.04.22 |
申请号 |
US19940246394 |
申请日期 |
1994.05.20 |
申请人 |
MERCK & CO., INC. |
发明人 |
MARBURG, STEPHEN;TOLMAN, RICHARD L.;KNISKERN, PETER J.;MILLER, WILLIAM J.;HAGOPIAN, ARPI;IP, CHARLOTTE C.;HENNESSEY, JR., JOHN P.;KUBEK, DENNIS J.;BURKE, PAMELA D. |
分类号 |
A61K39/00;A61K38/16;A61K39/02;A61K39/09;A61K39/095;A61K39/295;A61K39/395;A61K47/36;A61P29/00;C07K;C07K1/113;C07K1/14;C07K14/00;C07K14/195;C07K14/22;C07K14/315;C07K14/41;C07K17/02;C07K17/10;C08B37/00;C12P19/04;C12P21/00;C12R1/36;C12R1/46;(IPC1-7):C07K17/02;A61K39/385 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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