| 摘要 |
PCT No. PCT/EP89/01251 Sec. 371 Date Jun. 19, 1990 Sec. 102(e) Date Aug. 13, 1990 PCT Filed Oct. 19, 1989 PCT Pub. No. WO90/04597 PCT Pub. Date May 3, 1990The invention relates to a method for the preparation of glycoconjugates of phosphorus amides with the general formula <IMAGE> 1 and <IMAGE> 1a where the connection of the sugar with the phosphoric acid amide mustard residue, and the ifosfamide mustard residue, respectively, occurs preferably in the 1-position, and where R1 and R2; which can be the same or different, denote hydrogen, lower C1-C4 alkyl or C1-C6 haloalkyl and where as sugar there can be present mono-, di-, or polysaccharides in all existing isomeric and enantiomeric forms, wherein in a known way protected brominated sugars are conjugated with the respective phosphorus compounds, and freed of the protective residues, and to the use of said compounds as anti-tumour drugs.
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