GENERATING D-PEPTIDES: METHODS AND COMPOSITIONS

摘要

Methods of making and using D-antibodies and D-peptides are provided. The D-peptides or D-antibodies are analogs of ligands or receptors capable of specifically binding L-peptides, peptides containing both L-amino acids and D-amino acids, chiral and achiral non-naturally occurring peptides, and chiral and achiral non-peptide compounds. The D-peptides or D-antibodies are resistant to proteolysis in the gut and throughout the body and are less immunogenic than their L-polypeptide or L-antibody counterparts. Methods for producing such D-peptides or D-antibodies are provided.