| 摘要 |
PCT No. PCT/JP96/02778 Sec. 371 Date Oct. 28, 1996 Sec. 102(e) Date Oct. 28, 1996 PCT Filed Sep. 26, 1996 PCT Pub. No. WO97/11961 PCT Pub. Date Mar. 3, 1997The peptide derivatives having endothelin receptor-antagonistic action or a salt thereof and medicinal compositions containing them are provided. Since peptide derivatives or a salt thereof of this invention exhibit remarkable endothelin receptor-antagonistic action with low toxicity, they are effective as medicines for prophylaxis and therapy of, for example, cardio- or cerebro-circulatory diseases hepatic diseases and/or renal diseases. |
