摘要 |
Compounds of formula (Ia) as potent, beta 1-specific beta blockers with a short duration of action in the systemic circulation, wherein R is 3',4'-dimethoxyphenyl, R<1> is hydrogen, and R<2> is selected from methyl, ethyl, propyl, isobutyl and isopropyl; or R is 3',4'-dimethoxyphenyl, R<1> is selected from fluorine, chlorine and bromine, and R<2> is selected from methyl, ethyl, propyl, isopropyl, isobutyl and cyclopropylmethyl; or R is 4'-methoxyphenoxy, R<1> is selected from hydrogen, fluorine, chlorine and bromine, and R<2> is selected from methyl, ethyl, propyl, isopropyl, isobutyl and cyclopropylmethyl; or R is 3',4'-dimethoxyphenyl, R<1> is cyano, and R<2> is cyclopropylmethyl; or R is 4'-methoxyphenoxy, R<1> is cyano, and R<2> is isobutyl; and physiologically acceptable hydrolysable derivatives thereof having the hydroxy group in the 2-position of the 3-aminopropoxy side chain in esterified form, in their racemic and optically active forms, and their pharmaceutically acceptable acid addition salts.
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申请人 |
THE UNIVERSITY OF MELBOURNE;LOUIS, WILLIAM, JOHN;JACKMAN, GRAHAM, PAUL;IAKOVIDIS, DIMITRIOS;LOUIS, SIMON, NICHOLAS, STEWART;DRUMMER, OLAF, HEINO |
发明人 |
LOUIS, WILLIAM, JOHN;JACKMAN, GRAHAM, PAUL;IAKOVIDIS, DIMITRIOS;LOUIS, SIMON, NICHOLAS, STEWART;DRUMMER, OLAF, HEINO |