SPECIFIC BINDING MEMBERS FOR HUMAN TRANSFORMING GROWTH FACTOR BETA; MATERIALS AND METHODS

摘要

Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGF beta ) bind specifically isoforms TGF beta 2 and TGF beta 1 or both, preferentially compared with TGF beta 3. Specific binding members may be isolated and utilised in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for a particularly advantageous specific binding member which binds the active form of TGF beta 2, neutralising its activity, but does not bind the latent form.