发明名称 |
USE OF CREATINE ANALOGUES FOR THE TREATMENT OF DISORDERS OF GLUCOSE METABOLISM |
摘要 |
The present invention relates to the use of creatine compounds including cyclocreatine and creatine phosphate for treating or preventing a metabolic disorder consisting of hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, insulin insensitivity, diabetes related diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include: (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as activators or inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter; (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group; (5) compounds which modify the association of creatine kinase with other cellular components.
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申请公布号 |
WO9713507(A1) |
申请公布日期 |
1997.04.17 |
申请号 |
WO1996US16365 |
申请日期 |
1996.10.11 |
申请人 |
AVICENA GROUP, INC.;DANA-FARBER CANCER INSTITUTE |
发明人 |
KADDURAH-DAOUK, RIMA;TEICHER, BEVERLY, A. |
分类号 |
A61K38/28;A61K31/00;A61K31/195;A61K31/197;A61K31/198;A61K31/395;A61K31/397;A61K31/40;A61K31/401;A61K31/415;A61K31/4168;A61K31/4172;A61K31/495;A61K31/64;A61K31/675;A61K31/685;A61P3/00;A61P3/10;G06G7/48;G06G7/58;(IPC1-7):A61K31/195 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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