| 摘要 |
<p>Pyrazolone derivatives represented by general formula (I) or salts thereof which have antiplatelet aggregation effects and thus are useful as a preventive or remedy for various thrombotic diseases. In said formula (I) X?1 and X2¿ represents (a), wherein A represents cyano, cyano(C¿1-4? alkyl), amino, amino-(C1-4 alkyl), amidino, guanidino, etc.; and R?1 and R2¿ independently represents each hydrogen, halogeno, C¿1-6? alkyl, etc.; another of X?1 and X2¿ represents C¿1-6? alkyl, C3-6 alkenyl, aryl(C1-4 alkyl) or aryl; one of Y?1 and Y2¿ represents (b), wherein Q represents oxygen or sulfur; Z1 represents oxygen, -NR7- or -CHR7-; Z2 represents cyclic C¿3-7? alkylene, C1-3 alkylene, -CH2CO-, -CH2CH2CO-, etc.; Z?3¿ represents oxygen, sulfur, sulfinyl, sulfonyl, etc.; Z4 represents C¿1-3? alkylene, etc.; and Z?5¿ represents carboxyl, etc.; and another of Y?1 and Y2¿ represents D-E-, wherein E represents a bond, C¿1-4? alkylene, phenylene, etc.; and D represents hydrogen, C1-6 alkyl, etc.</p> |
