Processes and intermediates for preparing macrocycles
摘要
Novel processes for the preparation of lactam- and lactone-containing macrocyles are provided. In preferred embodiments, rapamycin and demethoxyrapamycin are prepared by a convergent synthesis regime. Intermediates useful in the synthetic processes are also provided.
申请公布号
US5621108(A)
申请公布日期
1997.04.15
申请号
US19940349413
申请日期
1994.12.05
申请人
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人
SMITH, III, AMOS B.;CONDON, STEPHEN M.;LEAZER, JR., JOHNNIE L.;MALECZKA, ROBERT E.;MCCAULEY, JOHN A.;LEAHY, JAMES W.