| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compounds, capable of inducing the expression of a protein for inhibiting cyclin-dependent kinases independently of a tumor suppressor gene product p53 by culturing a compound microorganism belonging to the genus Pseudomonas in a culture medium. SOLUTION: The new compounds are FR190895 (C23 H24 N2 O7 having 102-105 deg.C melting point), FR190872 (C23 H24 N2 O6 having 104-107 deg.C melting point) and FR190873 (C23 H24 N2 O6 ). The compounds are obtained by culturing a microoganisms, belonging to the genus Pseudomonas and capable of producing at least one compound of the FR190895, FR190872 and FR190873, etc., [e.g. Pseudomonas chlororaphis No.4306 strain (FERM BP-5232)] in a nutrient culture medium and collecting the resultant product from the obtained cultured product. The compounds are readily soluble in methanol, chloroform and dimethyl sulfoxide and insoluble in water and capable of manifesting the positivity to the cerium sulfate and iodine vapor reactions and the negativity to the ninhydrin, ferric chloride and Molisch reactions. All of the compounds are a light-yellow powder. |
