CARBOSTYRIL DERIVATIVES AS ANTITHROMBOTIC AGENTS

摘要

A carbostyril derivative of formula (1), wherein A is lower alkylene, R is H, halogen or lower alkoxy, R1 and R2 are each lower alkyl being optionally substituted by OH, lower alkoxy, phenyl-lower alkoxy or lower alkanoyloxy; cycloalkyl being optionally substituted by OH, hydroxy-lower alkoxy or lower alkanoyloxy; or amino being optionally substituted by lower alkyl or cycloalkyl,R3 is H, lower alkyl, lower alkenyl or hydroxy-lower alkyl, and the bond between3- and 4-positions of the carbostyril nucleus is single or double, provided thatwhen R and R3 are H, R1 and R2 should not be either unsubstituted lower alkyl orunsubstituted cycloalkyl, or a salt thereof, which shows antithrombotic activities, intima thickening inhibitory activity, the platelet mass dissociating activity and increasing activity of the blood flow in the brain and the peripheral vessel, and hence, is useful as medicines in the prophylaxis or treatment of various ischemic diseases.