BIFUNCTIONAL SULFIDE-CONTAINING SULFONAMIDE-CHELATING AGENTS SUCH AS XSNY FOR RADIOACTIVE ISOTOPES

摘要

New compounds have the general formula (I): M - L, in which M stands for a radio-isotope of Tc or Re and L stands for a ligand having the general formula (II): B-CR1R2-(CR3R4)n=1,2-S-CHR5-CHR6-SO2-NH-CR7R8-(CR9R10)m=1,2-D, in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 may have various meanings and B and D stand for another group which is suitable for binding metal ions by coordination and for coupling to selectively enriching compounds. Coupling to selectively enriching compounds may alternatively also be mediated by R8. These new compounds are useful for complexing technetium and rhenium and are used for medical diagnosis and therapy.