Verfahren zur Herstellung von Cephem-Derivaten

摘要

The present invention provides a process for preparing a cephem derivative characterized in that an allenyl beta -lactam compound represented by the formula (1) wherein R<1> is amino or protected amino, R<2> is a hydrogen atom or lower alkoxyl, R<3> is a hydrogen atom or carboxylic acid protecting group and X is the group -SO2R<4> or -SR<4>, R<4> being substituted or unsubstituted aryl or substituted or unsubstituted nitrogen-containing aromatic heterocyclic group is reacted with a nucleophilic agent to obtain the derivative, the cephem derivative being represented by the formula (2) wherein R<1>, R<2> and R<3> are as defined above, and Y is the residue of the nucleophilic agent.