| 摘要 |
FIELD: organic chemistry. SUBSTANCE: product: compounds of the formula (I) b and their pharmaceutically acceptable salts where:- halogen, removing group bound through oxygen that involves simple aromatic ether, aromatic ester, alkylsulfonate, arylsulfonate, alkylphosphonate, arylphosphonate, alkylphosphate or arylphosphate; R- Ror; NH(CHR)OH means H or alkyl; Rmeans H, free or substituted aryl, heteroaryl or alkyl; Rand Rmean independently H, lower alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl or lower cycloalkyl; m = 1-6, and n = 2-6. Invention relates to also pharmaceutical compositions containing compounds and a method of inhibition of interleukin-1R-protease activity in mammalian using compounds and compositions. EFFECT: improved method of synthesis, enhanced effectiveness of enzyme inhibition. |
