发明名称 |
PREPARATION OF GLUCOSAMINYL MURAMIC ACID DERIVATIVES |
摘要 |
The present invention provides a method for the preparation of disaccharides, such as glucosaminyl muramic acids peptides and derivatives. The method includes condensing a protected muramic acid ester with a 1-organothio- or 1fluoroglucosamine derivative in the presence of a suitable promoter to produce a protected glucosaminyl muramic acid ester. The protected glucosaminyl muramic acid ester may be used to prepare disaccharide peptides, such as Nacetylglucosaminyl-N-acetylmuramyl dipeptides, which have demonstrated immunological activity. Protected muramic acid esters and 1-organothio- or 1fluoro-glucosamine compounds which may be employed as intermediates in the method are also provided.
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申请公布号 |
CA2231505(A1) |
申请公布日期 |
1997.04.10 |
申请号 |
CA19962231505 |
申请日期 |
1996.09.26 |
申请人 |
ENDOREX CORPORATION |
发明人 |
MA, FANFENG;VOSIKA, GERALD J. |
分类号 |
C07H15/23;A61K31/7012;A61K38/00;A61P37/02;C07H15/00;C07H15/04;C07H15/18;C07K5/062;C07K9/00;(IPC1-7):C07H15/18 |
主分类号 |
C07H15/23 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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