Compositions and methods for inhibiting the binding of pecam

摘要

The present invention is directed to an isolated and purified linear peptide of from 4 to about 13 residues modeled after a C2-type, IG domain of the PECAM-1 peptide. A peptide of this invention can be linear or cyclic and has the amino acid residue sequence of any SEQ ID NOs: 2-105. The present invention is further directed to a process of selectively inhibiting the binding of PECAM-1 to itself comprising exposing a first cell that expresses PECAM-1 to a second cell that expresses PECAM-1 in the presence of an effective inhibiting amount of such a peptide. The present invention is still further directed to a pharmaceutical composition comprising a physiologically acceptable carrier and a peptide of the invention.