DNA MOLECULES STABILIZED BY MODIFICATIONS OF THE 3'-TERMINAL PHOSPHODIESTER LINKAGE AND THEIR USE AS NUCLEIC ACID PROBES AND AS THERAPEUTIC AGENTS TO BLOCK THE EXPRESSION OF SPECIFICALLY TARGETED GENES

摘要

The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.