发明名称 Xsns-type bi-functional sulphide-containing sulphonamide chelating agents for radioactive isotopes
摘要 The invention pertains to novel compounds of the general formula (I): M - L in which M stands for a radioisotope of Tc or Re, L stands for a ligand of the general formula (II): B-CO-(CR<1>R<2>)n=1,2-S-CHR<3>-CHR<4>-SO2-NH-CR<5>R<6>-(CR<7>R<8>)m=1,2-SR<9> in which R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8> and R<9> can have different meanings, and B stands for another group which is suitable both for the dative bond of metal ions and for coupling with selectively concentrating compounds. That coupling can alternatively be effected on R<8>. These novel compounds serve to form complexes of technetium and rhenium and are used in medical diagnostics and therapy.
申请公布号 AU1435997(A) 申请公布日期 1997.04.09
申请号 AU19970014359 申请日期 1996.09.19
申请人 INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAT 发明人 LUDGER DINKELBORG;CHRISTOPH STEPHAN HILGER;WOLFGANG KRAMP;DR. JOHANNES PLATZEK;BERND RADUCHEL DR.;SEBASTIAN ERBER
分类号 A61K38/00;A61K51/04;A61K51/08;C07B59/00;C07C5/00;C07C323/67;C07F13/00;C07K14/575 主分类号 A61K38/00
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