摘要 |
Disclosed is a method for inhibiting the biological degradation of a synthetic oligodeoxynucleotide or oligodeoxynucleotide analog placed into a cell or extracellular environment. Biological degradation is inhibited by the covalent attachment of a protection moiety, e.g., a fluorochrome label such as FITC or Texas red, to a modified base incorporated into the oligodeoxynucleotide or oligodeoxynucleotide analog. |