发明名称 |
Percutaneous absorption preparation |
摘要 |
A percutaneous absorption preparation which is excellent in the skin penetration of a non-narcotic analgesic buprenorphine and can sustain a high blood level in a stable state over a long period of time is provided. The percutaneous absorption preparation for administrating buprenorphine hydrochloride and/or buprenorphine, which comprises a support having on one surface thereof a plaster layer containing a pressure-sensitive adhesive, buprenorphine hydrochloride and/or buprenorphine, and a penetration enhancer, wherein the penetration enhancer comprises a combination of a monoglyceride of a fatty acid having 6 to 8 carbon atoms and isopropyl myristate, and the plaster layer contains at least 10% by weight of a monoglyceride off fatty acid having 6 to 8 carbon atoms and at least 5% by weight off isopropyl myristate, with the proviso that the content of the whole penetration enhancer ranges from 25 to 50% by weight. The combined use of the fatty acid monoglyceride and isopropyl myristate as a penetration enhancer synergistically elevates skin penetration of buprenorphine hydrochloride and/or buprenorphine.
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申请公布号 |
US5618555(A) |
申请公布日期 |
1997.04.08 |
申请号 |
US19950430384 |
申请日期 |
1995.04.28 |
申请人 |
ITTO DENKO CORPORATION;NIKKEN CHEMICALS CO., LTD. |
发明人 |
TOKUDA, SHOICHI;NINOMIYA, KAZUHISA;FUKUSHIMA, YASUHIRO;WATANABE, SHIGEYUKI;OCHIAI, MITSURU;OKUMURA, MUTSUO;HOSOKAWA, YUKO |
分类号 |
A61K9/00;A61K9/70;A61K31/485;A61K47/14;A61P25/04;(IPC1-7):A61F13/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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