| 摘要 |
PROBLEM TO BE SOLVED: To obtain an agent for inhibiting the agglomeration and/or deposition of amyloid protein, capable of preventing the production of amyloid and effective for Alzheimer's disease, II type diabetes, etc. SOLUTION: This amyloid protein agglomeration-inhibiting agent contains a thionaphthalene derivative of the formula [R is a 1-5C alkyl substituted with OH or COOR<4> (R<4> is H, a 1-10C alkyl, etc.), an aryl, etc.; R<1> , R<2> are each H, a 1-5C alkyl, phenyl; R<3> is H, a 1-5C alkyl, a 1-4C alkoxycarbonyl] or its salt in an amount of 1-70wt.%, preferably 5-50wt.%, as an active ingredient. The active ingredient is administered at a daily dose of 10-1000mg/person, preferably 100-600mg/person. The amyloid protein agglomeration-inhibiting agent can inhibit the agglomeration of amylin and amyloid-βprotein which are amyloid proteins, etc., and is useful for treating and preventing Alzheimer's disease, II type diabetes, etc., which are characterized by the deposition of the amyloid in specific organs.
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