Sodium orthohydroxylate-phenol-water complexes, process for preparing same and application for isolation of sodium orthohydroxymandelate

摘要

Prepn. of the complex crystallised ortho-hydroxymandelate of sodium/phenol/water is by adding phenol in an aq. soln. at pH 7-9 then crystallising. The aq. soln. is obtd. by reacting phenol on glyoxylic acid in presence of a tert. amine and trivalent cation followed by treatment with an alkaline hydroxide soln. Also claimed are: (A) the complex äIper seIü; (B)äH use of the complex to prepare sodium ortho-hydroxymandelate of formula (II); and @GRAPHIC = O: DNA RINT 719 P 67162.A1 one half .STR,1249,362,0 (C)äH prepn. of complex (II) is by treating the above complex with a mixt. of water/organic solvent S' whereby S' is immiscible in water but soluble in the phenol. äUMORE SPECIFICALLYUü The complex has formula (I): @GRAPHIC = O: DNA RINT 719 P 67162.A1 .STR,1249,320,0 n, m = 0.8-1.2. äU