| 摘要 |
<p>The present invention is related to a method of identifying therapeutic compounds and vaccines active against Helicobacter pylori infections comprising an in vivo animal model. The method is characterized by inoculation of an immunologically competent rodent animal selected from the group of NZB mice, DBA mice, KK mice or a rat with a H. pylori strain associated with gastritis in humans and thereafter to the infected animal administration of a test compound or a vaccine candidate and determination of the effectiveness of said compound or vaccine on the infection. The invention also relates to the use of said animal model in the development of diagnostic tests for such infections, as well as a New Zealand Black (NZB) mouse infected with human Helicobacter pylori strains.</p> |
