MATERIALS AND METHODS RELATING TO THE TRANSFER OF NUCLEIC ACID INTO QUIESCENT CELLS
摘要
Materials and methods for transferring nucleic acid encoding a polypeptide for treating a disease or disorder into populations of quiescent cells such as haematopoietic stem cells (HSCs), using retroviral packaging cell lines and retroviral particles expressing and displaying a growth factor such as stem cell factor (SCF) on the cell surface or as a fusion with a viral envelope protein. The present invention also relates to compositions comprising the retroviral packaging cell lines and retroviral particles, and their use in methods of medical treatment, in vivo and ex vivo.
申请公布号
WO9712049(A1)
申请公布日期
1997.04.03
申请号
WO1996GB02405
申请日期
1996.09.30
申请人
MEDICAL RESEARCH COUNCIL;RUSSELL, STEPHEN, JAMES;FIELDING, ADELE, KAY;CASIMIR, COLIN, MAURICE
发明人
RUSSELL, STEPHEN, JAMES;FIELDING, ADELE, KAY;CASIMIR, COLIN, MAURICE