PRODUCT AND PROCESS TO REGULATE ACTIN POLYMERIZATION

摘要

The present invention relates to methods useful for identifying compounds capable of specifically regulating actin polymerization, stress fiber formation or focal adhesion assembly by regulating G alpha12 and/or G alpha13 activity in cells involved in inflammatory responses, immune responses, allergic responses and neuronal responses. The invention also describes kits to perform these assays and methods to control disease related to such responses. The figure illustrates stress fiber formation in Swiss 3T3 cells microinjected with expression plasmids encoding constitutively activated Rho, G alpha12 and G alpha13 protein.