| 摘要 |
<p>A method for treating mammals who are infected with a mycobacterium wherein the mycobacterium produces a urease. The method involves treating the mammal with an anti-urease agent to reduce the production of urease by the mycobacterium and thereby reduce biological activity of the mycobacterium. Anti-urease agents include urease inhibitors and oligodeoxynucleotides anti-sense to the urease gene or messenger RNA derived therefrom which prevents expression of urease by the mycobacterium. Methods for screening compounds for potential use as anti-mycobacterial agents are also disclosed as is the identity of urease produced by M. tuberculosis. The urease provides a target to which anti-bacterial agents can be directed.</p> |
