| 摘要 |
<p>Disclosed is a recombinant viral particle capable of infecting a eukaryotic cell, the viral particle comprising: a substantially intact viral glycoprotein fused, via an intervening linker region, to a heterologous polypeptide displayed on the surface of the particle, which heterologous polypeptide modulates the ability of the viral particle to infect one or more eukaryotic cell types and is cleavable from the viral glycoprotein by a protease acting selectively on a specific protease cleavage site present in the linker region, such that cleavage of the heterologous polypeptide from the viral glycoprotein allows the glycoprotein to interact normally with its cognate receptor on the surface of a target cell.</p> |
