5-Ht1f mediated inhibition of neurogenic meningeal extra-vasation a method for the treatment of migraine

摘要

The present invention provides a method for the treatment of migraine and associated disorders which relies on a novel mechanism of action. By treating a migraineur with compounds or compositions which are selective agonists of 5-HT1F receptors relative to other serotonin receptors which produce unwanted effects like vasoconstriction, the neurogenic meningeal extravasation which leads to the pain of migraine is inhibited and the physiological liabilities of compounds exhibiting vasoconstriction or other side effects are avoided.