Drug delivery composition containing chitosan or derivative thereof having a defined z.potential

摘要

A drug delivery composition for administration to mucosa is provided. The composition comprises a pharmacologically active compound and particles, preferably powder or microspheres, of chitosan or a chitosan derivative or salt wherein the particles are either solidified or partially cross-linked such that they have a zeta-potential of +0.5 to +50 mV. Solidified particles are made by treating particles made from a water soluble chitosan salt with an alkaline agent such as sodium hydroxide in non-acid containing water to render them insoluble.