发明名称 |
Tumor immunotherapy using anti-idiotypic antibodies |
摘要 |
The present invention relates to methods which utilize anti-idiotypic antibodies, or fragments thereof, for tumor immunotherapy or immunoprophylaxis. Monoclonal anti-idiotypic antibodies which recognize an idiotype present on a second antibody or on a T lymphocyte or on an immune suppressor factor which is directed against a defined tumor antigen, can be used for immunization against a tumor, for immune anti-tumor activation or inhibition of suppression, or for in vitro activation of lymphocytes to be used in adoptive immunotherapy. The anti-idiotypic antibodies, or fragments thereof, can also be used to monitor anti-antibody induction in patients undergoing passive immunization to a tumor antigen by administration of anti-tumor antibody. In another embodiment, administration of T lymphocytes which express an idiotype directed against a defined tumor antigen can be used to transfer delayed-type hypersensitivity to the tumor. In another method of the invention, the induction of anti-idiotypic antibodies in vivo by administration of anti-tumor antibody or immune cells or factors exhibiting an anti-tumor idiotype can be therapeutically valuable. |
申请公布号 |
EP0306995(B1) |
申请公布日期 |
1997.04.02 |
申请号 |
EP19880114834 |
申请日期 |
1988.09.09 |
申请人 |
ONCOGEN LIMITED PARTNERSHIP |
发明人 |
HELLSTROM, INGEGERD;HELLSTROM, KARL FRIK;KAHN, MARIA S.;BEATON, DONNA FRANCINE;LEE, VICTOR K. |
分类号 |
A61K;A61K38/00;A61K39/00;A61K39/395;A61P35/00;C07K16/28;C07K16/30;C07K16/42;C12N;C12N5/00;C12N15/00;C12P21/08;C12R1/91;G01N33/574;G01N33/577 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|