发明名称 |
Microcapsules comprising 2-piperazinone-1-acetic acid compounds |
摘要 |
<p>A microcapsule containing an amorphous water-soluble 2-piperazinone-1-acetic acid compound or salt thereof and a polymer and a method of preparing said microcapsule, which comprises dispersing in an aqueous phase a dispersion of the amorphous water-soluble 2-piperazinone-1-acetic acid compound or salt thereof in a solution of a polymer in an organic solvent to give an s/o/w type emulsion and subjecting the emulsion to in-water drying. The sustained-release microcapsule which is advantageous in entrapping 2-piperazinone-1-acetic acid compound or the salt thereof as a drug in a high concentration, and in the reduced initial release of the drug, thereby reducing undesirable side effects of the drug.</p> |
申请公布号 |
EP0765660(A2) |
申请公布日期 |
1997.04.02 |
申请号 |
EP19960115476 |
申请日期 |
1996.09.26 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
TAKADA, SHIGEYUKI;KUROKAWA, TOMOFUMI;IWASA, SUSUMU |
分类号 |
A61K9/16;A61K9/52;A61K31/495;(IPC1-7):A61K9/50 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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