| 发明名称 |
(R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans |
| 摘要 |
PCT No. PCT/SE94/01010 Sec. 371 Date Jan. 4, 1995 Sec. 102(e) Date Jan. 4, 1995 PCT Filed Oct. 26, 1994 PCT Pub. No. WO95/11891 PCT Pub. Date May 4, 1995Compounds of the general formula <IMAGE> (I) wherein R1 is n-propyl or cyclobutyl; R2 is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl; R3 is hydrogen; R4 is hydrogen or methyl; as (R)-enantiomer in the form of free base or pharmaceutically acceptable salts thereof, process for their preparation, pharmaceutical composition, use of and method of treatment of disorders in CNS.
|
| 申请公布号 |
US5616610(A) |
申请公布日期 |
1997.04.01 |
| 申请号 |
US19950362544 |
申请日期 |
1995.01.04 |
| 申请人 |
ASTRA AKTIEBOLAG |
发明人 |
EVENDEN, JOHN L.;HAMMARBERG, EVA M.;HANSSON, HANS S.;HELLBERG, SVEN E.;JOHANSSON, LARS G.;LUNDKVIST, JOHAN R. M.;ROSS, SVANTE B.;SOHN, DANIEL D.;THORBERG, SETH O. |
| 分类号 |
A61K31/353;C07D311/58;C07D335/06;C07D405/04;C07D405/12;C07D407/04;C07D409/04;C07D409/06;C07D409/12;C07D413/04;C07D413/06;C07D417/12;(IPC1-7):A61K31/35;C07D311/20 |
主分类号 |
A61K31/353 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
