发明名称 |
Human T-cell leukemia virus transcription modulators and screening assays |
摘要 |
The invention provides methods and compositions relating to the Tax-response Complex-1 (TRC-1) a transcription complex associated with disease, particularly HTLV infection. TRC-1 is composed of novel forms of JunB and a member of a novel protein family called small nuclear factors or SNFs. The expression of these compounds are shown to correlate with cell lineage, activation and infection. SNFs and T-cell specific forms of JunB, find particular use in screening assays for agents or lead compounds for agents useful in the diagnosis, prognosis or treatment of disease, particularly HTLV infection. Nucleic acids encoding SNFs, and SNF-specific binding agents find use in diagnosis and as commercial reagents for the biopharmaceutical industry.
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申请公布号 |
US5616475(A) |
申请公布日期 |
1997.04.01 |
申请号 |
US19950383761 |
申请日期 |
1995.02.03 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
WACHSMAN, WILLIAM;MARTIN, TRACY;KLUMP, WOLFGANG |
分类号 |
A61K38/00;C07K14/47;(IPC1-7):C12P21/06;C12N1/00;C12N5/10;C12N15/12 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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