发明名称 |
Processes and devices for continuously monitoring levels of analyte |
摘要 |
In a process and devices or continuously measuring the concentration of an analyte in tissue. The tissue is provided with a hollow fiber having a pore size between the size of the analyte and the size of macromolecules, hollow fiber is perfused with a solution compatible with the tissue, and that solution is supplied from the hollow fiber through a reactor for the analyte. The reactor has a second hollow fiber having a pore size between the size of the analyte and the size of macromolecules, and the second hollow fiber is located in a container which contains macromolecular reactants for detecting the analyte and a signal producing system coupled therewith. The perfusion fluid is fed from the reactor to an eliminator for the analyte, whereby at least 95% of the remaining analyte is removed from the perfusion fluid and the perfusion fluid is reintroduced into said first hollow fiber. The process and devices operate as a closed circuit and therefore this method can be continued over a longer period of time than known methods, without the need to replace reservoirs.
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申请公布号 |
US5615671(A) |
申请公布日期 |
1997.04.01 |
申请号 |
US19960680280 |
申请日期 |
1996.07.11 |
申请人 |
SIEMENS-ELEMA AB;RIJKSUNIVERSITEIT TE GRONINGEN |
发明人 |
SCHOONEN, ADELBERT J. M.;SCHMIDT, FRANSISCUS J.;WIENTJES, KLAAS-JAN C. |
分类号 |
A61B5/145;A61B5/00;A61B5/1473;A61B5/1486;A61M1/36;(IPC1-7):G01N27/404 |
主分类号 |
A61B5/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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