| 摘要 |
Imidazoloquinoxalinones have the formula (I), in which R<1> stands for hydrogen, branched or linear C1-5-alkyl or a phenyl, pyridyl or thienyl group possibly substituted by one to two chlorine atoms, a trifluoromethyl, a nitrodioxy or a methylene dioxy group; R<2> stands for hydrogen, C1-5-alkyl or C3-8-dialkylaminoalkyl; R<3> stands for a chlorine or bromine atom, a trifluoromethyl, cyano or nitro group; A stands for a five-membered heterocycle with 1-4 nitrogen atoms or 1-2 nitrogen atoms and one oxygen or sulphur atom possible substituted by R<4> and R<5>; the radicals R<4> and R<5>, that may be the same or different, stand for hydrogen, C1-5-alkyl, C1-5-hydroxyethyl, phenyl, phenyl substituted by a chlorine atom, a trifluoromethyl or nitro group, -CHO, -COOH, -COO-C1-5-alkyl, -CH2-NR<6>R<7> (in which R<6> = H, C1-5-alkyl, R<7> = H, C1-5-alkyl), -CH2-NH-CO-R<8> (in which R<8> = C1-5-alkyl, phenyl, a phenyl group or an heteroaryl group possibly substituted by a chlorine atom of a nitro or trifluoromethyl group) or -CH2-NHCONHR<8>; and B stands for a bond or a C1-5-alkylene chain. Also disclosed are the tautomer and isomer forms of these compounds, as well as their physiologically compatible salts. These new substances have good glutamate antagonistic effects and are useful for controlling neurodegenerative diseases. |
