| 摘要 |
This invention relates to methods for the prevention or treatment of programmed cell death, or apoptosis, in neuronal cells for therapy in connection with neurodegenerative diseases, as well as methods of treatment of cancer and other tumorigenic diseases and herpesvirus infection. The invention also relates to assay methodologies allowing for the identification of substances capable of modulating the effects of the gamma 134.5 gene or modified gamma 134.5 gene or their protein expression products (ICP34.5) or modified, i.e., substances capable of potentiating, inducing, or inhibiting their effects. Additionally, the invention also relates to assay methodologies desinged to identify candidate substances able to mimic either gamma 134.5 expression or the activity of ICP34.5. The invention also relates to methods of delivering genes to cells for gene therapy. |
