Tetrahydrobenzimidazole derivatives

摘要

Tetrahydrobenzimidazole derivatives represented by formula (I) : wherein Het represents a heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl-lower alkyl group, an aralkyl group, a lower alkoxy group, a nitro group, a hydroxyl group, a lower alkoxycarbonyl group, and a halogen atom; and X represents a single bond or -NH- which is bonded to a carbon atom or nitrogen atom of the heterocyclic ring, and pharmaceutically acceptable salts thereof. These compounds exhibit antagonism against 5-HT3 receptor.