发明名称 |
METHOD AND COMPOSITIONS FOR INHIBITING ANGIOGENESIS |
摘要 |
<p>Pharmaceutical compositions for delivering an effective dose of an angiogenesis inhibitor consisting of a specific inhibitor of collagenase, for inhibition of blood vessel ingrowth and tube formation in vivo and capillary endothelial cell proliferation and migration in vitro, which is non-cytotoxic to normal cells. The compositions are delivered topically or locally using implants or injection. Examples of specific collagenase inhibitors include purified cartilage-derived inhibitor, collagenase binding peptides and antibodies which block the active site or metal binding regions of collagenase, and compounds which inhibit enzymes activating collagenase, such as plasmin inhibitor.</p> |
申请公布号 |
GR3021925(T3) |
申请公布日期 |
1997.03.31 |
申请号 |
GR19960403330T |
申请日期 |
1996.12.06 |
申请人 |
CHILDREN'S HOSPITAL |
发明人 |
MOSES, MARSHA, A.;SUDHALTER, JUDITH |
分类号 |
A61K38/55;A61K38/00;A61K39/395;A61P17/00;A61P27/02;A61P35/00;A61P43/00;C07K14/81;C07K16/40;(IPC1-7):A61K38/00;A61K39/00;C07K2/00;C12N5/00 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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