Process for the enzymatic preparation of 7-amino-cephalosporanic acids

摘要

7-amino-cephalosporanic acids having the formula are obtained by submitting compounds having the following formula to enzymatic conversion: wherein R represents H, OH, O-CO-R'', R'' being an alkyl radical with from 1 to 4 carbon atoms, R<1> represents a carboxylic group. The reaction is carried out in the presence of a micro-organism selected from the Pseudomonas, Bacillus, Achromobacter genera, or in the presence of the enzyme, either free or immobilized, derived therefrom.