SULFONAMIDE DERIVATIVES

摘要

Sulfonamide derivatives of the formula (I) <IMG> (I) wherein R1 is, inter alia, alkyl, alkoxy, hydroxy, keto, nitro, halogen, trihalomethyl, cyano, amidino and -COOR7 (in which R7 is hydrogen or alkyl), n is an integer from 0 to 5; <IMG> is a carbocyclic ring or heterocyclic ring; <IMG> is <IMG> in which R2 and R3 each is hydrogen, alkyl, alkoxy, halogen, trihalomethyl or phenyl, or R2 and R3, taken together, represent alkylidene, or <IMG> is <IMG> in which R2 and R3, taken together with the carbon atom to which they are attached represent cycloalkyl; R4 is alkyl or alkoxy or two of R4, attached to the benzene nucleus at ortho positions relative to each other, taken together, represent alkylene; m is an integer from 0 to 4; and <IMG> is optionally substituted amino or a nitrogen-containing ring, are described as new pharmaceutical compounds having inhibitory activity or elastase.