SERINE DERIVATIVES SUBSTITUTED WITH HETEROCYCLES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

A serine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having an anti-PCP(phencyclidine) activity and being useful as a psychotropic, wherein X represents sulfur or oxygen; Y represents nitrogen or CH; R<1> and R<2> represent each independently hydrogen, lower alkyl or an amino-protecting group, or R<1> and R<2> may be combined together to form 4- to 9-membered nitrogenous cycloalkyl; R<3> represents hydrogen, carboxy, protected carboxy, aralkyl, or lower alkyl which may be hydroxylated; R<4> represents hydrogen or hydroxy; R<5> represents hydrogen or lower alkyl; A represents lower alkylene; B represents (1) an (un)saturated 4-to 10-membered nitrogenous cycloalkyl group which may be substituted by lower alkyl or aralkyl, or (2) a bicyclic nitrogenous hydrocarbon ring group comprising a 4- to 8-membered nitrogenous cycloalkyl group and a benzene ring fused together; and ... represents a single or a double bond.