| 摘要 |
<p>A genetic mutation within the SR calcium release channel provides a test for susceptibility to idiopathic dilated cardiomyopathy. The test detects the presence of the mutation in a sample of nucleic acids obtained from the individual being tested. Restriction fragment length polymorphism is one technique which can be used in the test. A transgenic mouse has a genome that includes at least one copy of a polynucleotide encoding a mutant SR Ca++ release channel. A method of alleviating symptoms associated with idiopathic dilated cardiomyopathy in a patient involves providing heart cells of the patient with a polynucleotide encoding a functional SR Ca++ release channel.</p> |
