USE OF HERPES VIRUS MUTANTS, VACCINE

摘要

FIELD: genetics, molecular biology. SUBSTANCE: invention relates to vaccine for prevention and control over animal diseases involving pseudorabies virus containing glycoprotein gp 50 and mutation in gene gp 50. Vaccines can be used against Aujeszky's disease (pseudorabies) or against other animal diseases if mutation is an insertion containing heterological gene that encodes antigen corresponding to this disease. Pseudorabies virus can contain additionally at least one mutation in gene gp 63 or g1. These vaccines can not be transferred from vaccinated to nonvaccinated animals. EFFECT: enhanced effectiveness of vaccines.