发明名称 |
Librairies of backbone-cyclized peptidomimetics |
摘要 |
Novel backbone-cyclized BPI peptide analogs and methods of making the same by the use of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are N<alpha>-functionalized amino acids constructed to include a spacer and a terminal functional group. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. A plurality of these Nalphaomega-functionalized amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis. |
申请公布号 |
AU6836196(A) |
申请公布日期 |
1997.03.27 |
申请号 |
AU19960068361 |
申请日期 |
1996.08.28 |
申请人 |
PEPTOR LIMITED;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF |
发明人 |
VERED HORNIK;CHAIM GILON |
分类号 |
G01N33/566;A61K38/00;C07K1/04;C07K5/00;C07K7/22;C07K7/56;C07K14/00;C07K14/655;C07K17/02;G01R31/3185 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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