NEUTRALIZING MONOCLONAL ANTIBODIES TO RESPIRATORY SYNCYTIAL VIRUS

摘要

The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratoy Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSVbinding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.