| 摘要 |
<p>An anti-inflammatory antisense drug which comprises a complex of a synthetic polyamino acid consisting of repeated sequences of lysine and serine residues or polyethylene glycol modifications thereof and an antisens oligonucleotide complementary to the partial or whole base sequence of an mRNA encoding physiologically active substances participating in human inflammatory diseases such as interleukin-1β, tumor necrotizing factor or α-cyclooxygenase. This drug enables efficacious treatment of inflammatory diseases such as rheumatoid arthritis, paradentitis, nephritis, ulcerous colitis, arterial sclerosis and psoriasis, septic shock, Crohn's disease, AIDS, intractable hepatic diseases, pathologies in association with liver transplant, etc.</p> |
