| 摘要 |
This invention relates to a method for the treatment of progressive renal failure and prevention of the progression of chronic renal failure in mammals by administration to a mammal in need thereof of a compound of formula (I) having the S,S-configuration, wherein R1 represents carbocyclic or heterocyclic monocyclic aryl, or biaryl; R3 represents hydrogen or carboxyl derived acyl; R4 represents hydrogen, lower alkyl, carbocyclic or heterocyclic aryl-lower alkyl, or biaryl-lower alkyl; COOR2 represents carboxyl or carboxyl derivatized in form of a pharmaceutically acceptable ester; n represents 2-6; or a pharmaceutically acceptable salt thereof. |
