| 发明名称 |
HUMAN GROWTH HORMONE VARIANTS |
| 摘要 |
Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugate d to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong the $i(in vivo) half-life of the variants.
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| 申请公布号 |
CA2658039(A1) |
申请公布日期 |
1997.03.27 |
| 申请号 |
CA19962658039 |
申请日期 |
1996.09.20 |
| 申请人 |
GENENTECH, INC. |
发明人 |
LOWMAN, HENRY B.;FUH, GERMAINE G.;WELLS, JAMES A.;CLARKE, ROSS G.;OLSON, KENNETH;CUNNINGHAM, BRIAN C. |
| 分类号 |
C07K14/61;C12N15/09;A61K31/00;A61K38/00;A61K38/27;A61K47/48;A61P3/00;A61P3/10;A61P5/00;A61P5/06;A61P5/08;A61P5/12;A61P13/12;A61P35/00;A61P37/00;A61P43/00;C07K1/107;C07K1/18;C07K17/08;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/18;C12N15/63;C12P21/02;C12R1/19 |
主分类号 |
C07K14/61 |
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